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Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis

Glutathione S-transferase (GST) genetic polymorphisms has been reported to be associated with osteosarcoma; however, the results of previous studies are conflicting. Thus, in the present study, a meta-analysis was conducted to investigate the effects of GSTM1 and GSTT1 polymorphisms on osteosarcoma...

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Autores principales: HAN, JICHENG, DENG, WEI, WANG, LAIYING, QI, WANLI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356414/
https://www.ncbi.nlm.nih.gov/pubmed/25789067
http://dx.doi.org/10.3892/ol.2015.2955
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author HAN, JICHENG
DENG, WEI
WANG, LAIYING
QI, WANLI
author_facet HAN, JICHENG
DENG, WEI
WANG, LAIYING
QI, WANLI
author_sort HAN, JICHENG
collection PubMed
description Glutathione S-transferase (GST) genetic polymorphisms has been reported to be associated with osteosarcoma; however, the results of previous studies are conflicting. Thus, in the present study, a meta-analysis was conducted to investigate the effects of GSTM1 and GSTT1 polymorphisms on osteosarcoma risk. A literature search was performed in the PubMed, Cochrane Library and China National Knowledge Infrastructure databases to identify case-control studies published prior to March 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In addition, Begg’s test was used to measure publication bias. Sensitivity analysis were performed to ensure the accuracy of the results. The meta-analysis results demonstrated no significant association between the null genotype of GSTM1 and osteosarcoma risk (OR=0.83; 95% CI, 0.37–1.85). By contrast, the results revealed a significant association for the comparison of null vs. non-null genotypes of GSTT1 (OR=1.54; 95% CI, 1.09–2.19). In conclusion, the GSTT1 null genotype may be associated with an increased risk of developing osteosarcoma. Further studies with larger sample sizes and well-designed methodologies are required to verify these conclusions.
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spelling pubmed-43564142015-03-18 Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis HAN, JICHENG DENG, WEI WANG, LAIYING QI, WANLI Oncol Lett Articles Glutathione S-transferase (GST) genetic polymorphisms has been reported to be associated with osteosarcoma; however, the results of previous studies are conflicting. Thus, in the present study, a meta-analysis was conducted to investigate the effects of GSTM1 and GSTT1 polymorphisms on osteosarcoma risk. A literature search was performed in the PubMed, Cochrane Library and China National Knowledge Infrastructure databases to identify case-control studies published prior to March 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In addition, Begg’s test was used to measure publication bias. Sensitivity analysis were performed to ensure the accuracy of the results. The meta-analysis results demonstrated no significant association between the null genotype of GSTM1 and osteosarcoma risk (OR=0.83; 95% CI, 0.37–1.85). By contrast, the results revealed a significant association for the comparison of null vs. non-null genotypes of GSTT1 (OR=1.54; 95% CI, 1.09–2.19). In conclusion, the GSTT1 null genotype may be associated with an increased risk of developing osteosarcoma. Further studies with larger sample sizes and well-designed methodologies are required to verify these conclusions. D.A. Spandidos 2015-04 2015-02-10 /pmc/articles/PMC4356414/ /pubmed/25789067 http://dx.doi.org/10.3892/ol.2015.2955 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
HAN, JICHENG
DENG, WEI
WANG, LAIYING
QI, WANLI
Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis
title Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis
title_full Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis
title_fullStr Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis
title_full_unstemmed Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis
title_short Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis
title_sort null genotypes of glutathione s-transferase μ1 and glutathione s-transferase θ1 are associated with osteosarcoma risk: a meta-analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356414/
https://www.ncbi.nlm.nih.gov/pubmed/25789067
http://dx.doi.org/10.3892/ol.2015.2955
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