Characterization of three alternative transcripts of the BRCA1 gene in patients with breast cancer and a family history of breast and/or ovarian cancer who tested negative for pathogenic mutations

The study of BRCA1 and BRCA2 genes and their alterations has been essential to the understanding of the development of familial breast and ovarian cancers. Many of the variants identified have an unknown pathogenic significance. These include variants which determine alternative mRNA splicing, ident...

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Detalles Bibliográficos
Autores principales: GAMBINO, GAETANA, TANCREDI, MARIELLA, FALASCHI, ELISABETTA, ARETINI, PAOLO, CALIGO, MARIA ADELAIDE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356434/
https://www.ncbi.nlm.nih.gov/pubmed/25683334
http://dx.doi.org/10.3892/ijmm.2015.2103

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