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γ-tocotrienol prevents 5-FU-induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5-FU-induced activation of Nrf2

Chemotherapy-induced oral mucositis is a common adverse event in patients with oral squamous cell carcinoma, and is initiated through a variety of mechanisms, including the generation of reactive oxygen species (ROS). In this study, we examined the preventive effect of γ-tocotrienol on the 5-FU-indu...

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Detalles Bibliográficos
Autores principales:	TAKANO, HIDEYUKI, MOMOTA, YUKIHIRO, KANI, KOUICHI, AOTA, KEIKO, YAMAMURA, YOSHIKO, YAMANOI, TOMOKO, AZUMA, MASAYUKI
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356501/ https://www.ncbi.nlm.nih.gov/pubmed/25625649 http://dx.doi.org/10.3892/ijo.2015.2849

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