Cargando…

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis

OBJECTIVE: Astaxanthin, a potent antioxidant, exhibits a wide range of biological activities, including antioxidant, atherosclerosis and antitumor activities. However, its effect on concanavalin A (ConA)-induced autoimmune hepatitis remains unclear. The aim of this study was to investigate the prote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jingjing, Xia, Yujing, Liu, Tong, Wang, Junshan, Dai, Weiqi, Wang, Fan, Zheng, Yuanyuan, Chen, Kan, Li, Sainan, Abudumijiti, Huerxidan, Zhou, Zheng, Wang, Jianrong, Lu, Wenxia, Zhu, Rong, Yang, Jing, Zhang, Huawei, Yin, Qin, Wang, Chengfen, Zhou, Yuqing, Lu, Jie, Zhou, Yingqun, Guo, Chuanyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356569/ https://www.ncbi.nlm.nih.gov/pubmed/25761053 http://dx.doi.org/10.1371/journal.pone.0120440

Ejemplares similares

Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis
por: Zhang, Huawei, et al.
Publicado: (2015)

The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling
por: Yu, Qiang, et al.
Publicado: (2018)

Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro
por: Li, Jingjing, et al.
Publicado: (2015)

N-Acetylcysteine Attenuates Ischemia-Reperfusion-Induced Apoptosis and Autophagy in Mouse Liver via Regulation of the ROS/JNK/Bcl-2 Pathway
por: Wang, Chengfen, et al.
Publicado: (2014)

Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice
por: Li, Jingjing, et al.
Publicado: (2015)

Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J(2) on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis
por: Chen, Kan, et al.
Publicado: (2015)

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis
por: Yin, Qin, et al.
Publicado: (2015)

15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity
por: Chen, Kan, et al.
Publicado: (2014)

By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice
por: Dai, Weiqi, et al.
Publicado: (2015)

Erratum to “15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity”
por: Chen, Kan, et al.
Publicado: (2014)

Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis
por: Li, Jingjing, et al.
Publicado: (2016)

Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway
por: Liu, Tong, et al.
Publicado: (2016)

Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice
por: Wang, Chengfen, et al.
Publicado: (2015)

Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-β1 Expression and Autophagy
por: Shen, Miao, et al.
Publicado: (2014)

The Protective Effect of Resveratrol on Concanavalin-A-Induced Acute Hepatic Injury in Mice
por: Zhou, Yingqun, et al.
Publicado: (2015)

K-ras Mutational Status in Cytohistological Tissue as a Molecular Marker for the Diagnosis of Pancreatic Cancer: A Systematic Review and Meta-Analysis
por: Yang, Jing, et al.
Publicado: (2014)

Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis
por: Cheng, Ping, et al.
Publicado: (2014)

Golgi protein 73 as a biomarker for hepatocellular carcinoma: A diagnostic meta-analysis
por: YANG, JING, et al.
Publicado: (2015)

Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis
por: Lu, Wenxia, et al.
Publicado: (2016)

Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis
por: Zhang, Yan, et al.
Publicado: (2015)

Oncogenic role of the Notch pathway in primary liver cancer (Review)
por: Lu, Jie, et al.
Publicado: (2016)

A meta-analysis of ursodeoxycholic acid therapy versus combination therapy with corticosteroids for PBC-AIH-overlap syndrome: evidence from 97 monotherapy and 117 combinations
por: Zhang, Huawei, et al.
Publicado: (2015)

Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3
por: Li, Sainan, et al.
Publicado: (2016)

Hydrogen Sulfide Ameliorates Ischemia/Reperfusion-Induced Hepatitis by Inhibiting Apoptosis and Autophagy Pathways
por: Cheng, Ping, et al.
Publicado: (2014)

The Synergistic In Vitro and In Vivo Antitumor Effect of Combination Therapy with Salinomycin and 5-Fluorouracil against Hepatocellular Carcinoma
por: Wang, Fan, et al.
Publicado: (2014)

Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy
por: Lu, Jie, et al.
Publicado: (2016)

Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis
por: Zhu, Rong, et al.
Publicado: (2014)

Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3
por: Xu, Ling, et al.
Publicado: (2016)

Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways
por: Deng, Jingfan, et al.
Publicado: (2018)

Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity
por: Mo, Wenhui, et al.
Publicado: (2018)

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy
por: Li, Jingjing, et al.
Publicado: (2016)

Combination Therapy of Ursodeoxycholic Acid and Corticosteroids for Primary Biliary Cirrhosis with Features of Autoimmune Hepatitis: A Meta-Analysis
por: Zhang, Yan, et al.
Publicado: (2013)

Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice
por: Li, Jingjing, et al.
Publicado: (2017)

In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
por: Li, Sainan, et al.
Publicado: (2016)

Corrigendum to “Ethyl Pyruvate Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Intrinsic Pathway of Apoptosis and Autophagy”
por: Shen, Miao, et al.
Publicado: (2016)

Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis
por: Zheng, Wei, et al.
Publicado: (2016)

Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway
por: Wu, Liwei, et al.
Publicado: (2017)

The long noncoding RNA TUG1 acts as a competing endogenous RNA to regulate the Hedgehog pathway by targeting miR-132 in hepatocellular carcinoma
por: Li, Jingjing, et al.
Publicado: (2017)

Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death
por: Li, Sainan, et al.
Publicado: (2017)

The protective effects of shikonin on hepatic ischemia/reperfusion injury are mediated by the activation of the PI3K/Akt pathway
por: Liu, Tong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_p0cniubelirhd7p5bcidhcfcm6