Effects on Murine Behavior and Lifespan of Selectively Decreasing Expression of Mutant Huntingtin Allele by Supt4h Knockdown

Production of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington’s disease (HD) and of a variety of other inherited degenerative neurological and neuromuscular disorders. Earlier work has shown that interference with...

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Detalles Bibliográficos
Autores principales: Cheng, Hui-Min, Chern, Yijuang, Chen, I-Hui, Liu, Chia-Rung, Li, Sih-Huei, Chun, Seung J., Rigo, Frank, Bennett, C. Frank, Deng, Ning, Feng, Yanan, Lin, Chyuan-Sheng, Yan, Yu-Ting, Cohen, Stanley N., Cheng, Tzu-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356588/
https://www.ncbi.nlm.nih.gov/pubmed/25760041
http://dx.doi.org/10.1371/journal.pgen.1005043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356588/
https://www.ncbi.nlm.nih.gov/pubmed/25760041
http://dx.doi.org/10.1371/journal.pgen.1005043

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