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Effects on Murine Behavior and Lifespan of Selectively Decreasing Expression of Mutant Huntingtin Allele by Supt4h Knockdown
Production of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington’s disease (HD) and of a variety of other inherited degenerative neurological and neuromuscular disorders. Earlier work has shown that interference with...
Autores principales: | Cheng, Hui-Min, Chern, Yijuang, Chen, I-Hui, Liu, Chia-Rung, Li, Sih-Huei, Chun, Seung J., Rigo, Frank, Bennett, C. Frank, Deng, Ning, Feng, Yanan, Lin, Chyuan-Sheng, Yan, Yu-Ting, Cohen, Stanley N., Cheng, Tzu-Hao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356588/ https://www.ncbi.nlm.nih.gov/pubmed/25760041 http://dx.doi.org/10.1371/journal.pgen.1005043 |
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