Computational Analysis of an Autophagy/Translation Switch Based on Mutual Inhibition of MTORC1 and ULK1

We constructed a mechanistic, computational model for regulation of (macro)autophagy and protein synthesis (at the level of translation). The model was formulated to study the system-level consequences of interactions among the following proteins: two key components of MTOR complex 1 (MTORC1), namel...

Descripción completa

Detalles Bibliográficos
Autores principales: Szymańska, Paulina, Martin, Katie R., MacKeigan, Jeffrey P., Hlavacek, William S., Lipniacki, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356596/
https://www.ncbi.nlm.nih.gov/pubmed/25761126
http://dx.doi.org/10.1371/journal.pone.0116550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356596/
https://www.ncbi.nlm.nih.gov/pubmed/25761126
http://dx.doi.org/10.1371/journal.pone.0116550

Ejemplares similares