Cargando…

Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects

Recent evidence shows that Alzheimer disease (AD) dementia in the oldest-old subjects was associated with significantly less amyloid plaque and fibrillary tangle neuropathology than in the young-old population. In this study, using quantitative (q) PCR studies, we validated genome-wide microarray RN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Wei, Wang, Jun, Varghese, Merina, Ho, Lap, Mazzola, Paolo, Haroutunian, Vahram, Katsel, Pavel L, Gibson, Gary E, Levine, Samara, Dubner, Lauren, Pasinetti, Giulio Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356684/ https://www.ncbi.nlm.nih.gov/pubmed/25784811 http://dx.doi.org/10.2147/NDT.S74898

Ejemplares similares

Is Alzheimer disease a failure of mobilizing immune defense? Lessons from cognitively fit oldest-old
por: Katsel, Pavel, et al.
Publicado: (2019)

Gain in Brain Immunity in the Oldest-Old Differentiates Cognitively Normal from Demented Individuals
por: Katsel, Pavel, et al.
Publicado: (2009)

Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer's Disease Cases
por: Ho, Lap, et al.
Publicado: (2012)

Microglia Activation in the Brain as Inflammatory Biomarker of Alzheimer’s Disease Neuropathology and Clinical Dementia
por: Xiang, Zhongmin, et al.
Publicado: (2006)

Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?
por: Akram, Afia, et al.
Publicado: (2010)

Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease
por: Katsel, Pavel, et al.
Publicado: (2013)

Correction:Cell Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease
por: Katsel, Pavel, et al.
Publicado: (2013)

Cognitive Decline and Dementia in the Oldest-Old
por: Kravitz, Efrat, et al.
Publicado: (2012)

Molecular signature of extracellular matrix pathology in schizophrenia
por: Pantazopoulos, Harry, et al.
Publicado: (2020)

Dementia in the oldest old: Beyond Alzheimer disease
por: Pierce, Aimee L., et al.
Publicado: (2017)

Increasing incidence of dementia in the oldest old: evidence and implications
por: James, Bryan D, et al.
Publicado: (2010)

Comparison of brain connectomes by MRI and genomics and its implication in Alzheimer’s disease
por: Woo, Young Jae, et al.
Publicado: (2020)

Population‐based analysis of pathological correlates of dementia in the oldest old
por: Tanskanen, Maarit, et al.
Publicado: (2017)

Prospective Study of Diet Quality and the Risk of Dementia in the Oldest Old
por: Flores, Ashley, et al.
Publicado: (2022)

Prospective Study of Diet Quality and the Risk of Dementia in the Oldest Old
por: Flores, Ashley C., et al.
Publicado: (2023)

Caloric Intake, Dietary Lifestyles, Macronutrient Composition, and Alzheimer' Disease Dementia
por: Pasinetti, Giulio Maria, et al.
Publicado: (2011)

Peroxisome Proliferator Activator Receptor Gamma Coactivator-1α Overexpression in Amyotrophic Lateral Sclerosis: A Tale of Two Transgenics
por: Varghese, Merina, et al.
Publicado: (2020)

Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease
por: Wang, Jun, et al.
Publicado: (2011)

Burden among Family Caregivers of Dementia in the Oldest-Old: An Exploratory Study
por: Win, Khin Khin, et al.
Publicado: (2017)

Oldest Old Patients Should be Recruited More in Clinical Trials of Dementia
por: Park, Young Ho
Publicado: (2018)

Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer’s Dementia in the Oldest Old
por: Melo van Lent, Debora, et al.
Publicado: (2021)

Health and social correlates of dementia in oldest‐old Mexican‐origin populations
por: Mejia‐Arango, Silvia, et al.
Publicado: (2020)

Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old
por: Lachner, Christian, et al.
Publicado: (2022)

FE65 Binds Teashirt, Inhibiting Expression of the Primate-Specific Caspase-4
por: Kajiwara, Yuji, et al.
Publicado: (2009)

Genome-wide12 DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease
por: Watson, Corey T., et al.
Publicado: (2016)

The expression of long noncoding RNA NEAT1 is reduced in schizophrenia and modulates oligodendrocytes transcription
por: Katsel, Pavel, et al.
Publicado: (2019)

CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer’s disease
por: Huang, Fang, et al.
Publicado: (2018)

Dementia in the oldest old: a multi-factorial and growing public health issue
por: Gardner, Raquel C, et al.
Publicado: (2013)

Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study
por: Hall, Anette, et al.
Publicado: (2019)

HEART FAILURE, ARRHYTHMIAS AND DEMENTIA IN THE “OLDEST OLD” OF SOUTH CENTRAL UNITED STATES
por: Duke, Brandon, et al.
Publicado: (2019)

Social Isolation and Incident Dementia in the Oldest-Old—A Competing Risk Analysis
por: Grothe, Jessica, et al.
Publicado: (2022)

The relationship between dopamine receptor D1 and cognitive performance
por: Tsang, Jonathan, et al.
Publicado: (2015)

Is there a neuropathology difference between mild cognitive impairment and dementia?
por: Haroutunian, Vahram, et al.
Publicado: (2009)

Brain Aging in the Oldest-Old
por: von Gunten, A., et al.
Publicado: (2010)

A Population-based study of dementia in the oldest old: the Monzino 80-plus Study
por: Lucca, Ugo, et al.
Publicado: (2011)

Likely Dementia and Its Implication for Support Among the Oldest-Old in Mexico and the United States
por: Lopez-Ortega, Mariana, et al.
Publicado: (2020)

Living Arrangements and Dementia Among the Oldest Old: A Comparison of Mexicans and Mexican Americans
por: Cantu, Phillip A, et al.
Publicado: (2022)

Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old
por: Melo van Lent, Debora, et al.
Publicado: (2022)

Genetic Variation in Healthy Oldest-Old
por: Halaschek-Wiener, Julius, et al.
Publicado: (2009)

Intravenous Thrombolytic Treatment in the Oldest Old
por: García-Caldentey, Juan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_2ch9ouutvndl8eucj70hrjg2qe