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Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study
BACKGROUND: To determine the relationships between regional white matter lesions (WMLs), lifestyle factors, and cognitive, motor function and mood. METHODS: A comprehensive evaluation, including brain MRI, blood tests, the Unified Parkinson's Disease Rating Scale, the Mini Mental State Examinat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356848/ https://www.ncbi.nlm.nih.gov/pubmed/25798332 http://dx.doi.org/10.1002/brb3.315 |
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author | Yamawaki, Mika Wada-Isoe, Kenji Yamamoto, Mikie Nakashita, Satoko Uemura, Yusuke Takahashi, Yoshimitsu Nakayama, Takeo Nakashima, Kenji |
author_facet | Yamawaki, Mika Wada-Isoe, Kenji Yamamoto, Mikie Nakashita, Satoko Uemura, Yusuke Takahashi, Yoshimitsu Nakayama, Takeo Nakashima, Kenji |
author_sort | Yamawaki, Mika |
collection | PubMed |
description | BACKGROUND: To determine the relationships between regional white matter lesions (WMLs), lifestyle factors, and cognitive, motor function and mood. METHODS: A comprehensive evaluation, including brain MRI, blood tests, the Unified Parkinson's Disease Rating Scale, the Mini Mental State Examination, and the Geriatric Depression Scale, was performed for people aged 65 years or older living in Ama-cho on October 1, 2009. Participants were classified by severity of periventricular hyperintensities (PVH) and deep white matter hyperintensities (DWMH) using the Fazekas score. RESULTS: Of 900 eligible participants, 688 (76.4%) were enrolled, including 303 men. Significant predictors of severe PVH were older age, lower low-density lipoprotein cholesterol (LDL-C) levels, elevated blood pressure (BP), cerebral infarction, and no current alcohol use. Significant predictors of severe DWMH were older age, lower 1,5-anhydroglucitol (1,5-AG) levels, elevated BP, cerebral infarction, and no current alcohol use. Higher cognitive function was associated with younger age, female sex, mild DWMH, more years of education, and higher high-density lipoprotein cholesterol levels. Depressive symptoms were associated with lower 1,5-AG levels, lower LDL-C levels, moderate to severe PVH, and no current alcohol use. CONCLUSIONS: White matter lesions in elderly people were related to hypertension and impaired glucose tolerance. The severity of WMLs was associated with cognitive function and mood. |
format | Online Article Text |
id | pubmed-4356848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43568482015-03-20 Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study Yamawaki, Mika Wada-Isoe, Kenji Yamamoto, Mikie Nakashita, Satoko Uemura, Yusuke Takahashi, Yoshimitsu Nakayama, Takeo Nakashima, Kenji Brain Behav Original Research BACKGROUND: To determine the relationships between regional white matter lesions (WMLs), lifestyle factors, and cognitive, motor function and mood. METHODS: A comprehensive evaluation, including brain MRI, blood tests, the Unified Parkinson's Disease Rating Scale, the Mini Mental State Examination, and the Geriatric Depression Scale, was performed for people aged 65 years or older living in Ama-cho on October 1, 2009. Participants were classified by severity of periventricular hyperintensities (PVH) and deep white matter hyperintensities (DWMH) using the Fazekas score. RESULTS: Of 900 eligible participants, 688 (76.4%) were enrolled, including 303 men. Significant predictors of severe PVH were older age, lower low-density lipoprotein cholesterol (LDL-C) levels, elevated blood pressure (BP), cerebral infarction, and no current alcohol use. Significant predictors of severe DWMH were older age, lower 1,5-anhydroglucitol (1,5-AG) levels, elevated BP, cerebral infarction, and no current alcohol use. Higher cognitive function was associated with younger age, female sex, mild DWMH, more years of education, and higher high-density lipoprotein cholesterol levels. Depressive symptoms were associated with lower 1,5-AG levels, lower LDL-C levels, moderate to severe PVH, and no current alcohol use. CONCLUSIONS: White matter lesions in elderly people were related to hypertension and impaired glucose tolerance. The severity of WMLs was associated with cognitive function and mood. Blackwell Publishing Ltd 2015-03 2015-02-03 /pmc/articles/PMC4356848/ /pubmed/25798332 http://dx.doi.org/10.1002/brb3.315 Text en © 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Yamawaki, Mika Wada-Isoe, Kenji Yamamoto, Mikie Nakashita, Satoko Uemura, Yusuke Takahashi, Yoshimitsu Nakayama, Takeo Nakashima, Kenji Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study |
title | Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study |
title_full | Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study |
title_fullStr | Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study |
title_full_unstemmed | Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study |
title_short | Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study |
title_sort | association of cerebral white matter lesions with cognitive function and mood in japanese elderly people: a population-based study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356848/ https://www.ncbi.nlm.nih.gov/pubmed/25798332 http://dx.doi.org/10.1002/brb3.315 |
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