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Predicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficients

BACKGROUND: Volume of distribution is an important pharmacokinetic property that indicates the extent of a drug’s distribution in the body tissues. This paper addresses the problem of how to estimate the apparent volume of distribution at steady state (Vss) of chemical compounds in the human body us...

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Detalles Bibliográficos
Autores principales:	Freitas, Alex A, Limbu, Kriti, Ghafourian, Taravat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356883/ https://www.ncbi.nlm.nih.gov/pubmed/25767566 http://dx.doi.org/10.1186/s13321-015-0054-x

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