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Drug-inducible synergistic gene silencing with multiple small hairpin RNA molecules for gene function study in animal model
Gene targeting is a critical tool for construction of disease models. However, the application of traditional homologous recombination-mediated gene knockout technology is limited by the absence of rapid frequency-guaranteed targeting methods. Although conventional small hairpin RNA (shRNA)-mediated...
Autores principales: | Ying, Ming, Chen, Guangfeng, Qiu, Yu, Shi, Xiujuan, Zhang, Chen, Wang, Qiuke, Yang, Shuzhang, Lu, Lixia, Yuan, Qionglan, Xu, Guotong, Jin, Zibing, Wu, Qiang, Liu, Xiaoqing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356887/ https://www.ncbi.nlm.nih.gov/pubmed/25271076 http://dx.doi.org/10.1007/s11248-014-9841-9 |
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