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Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications
Bioorthogonal chemistry has recently emerged to be one of the most powerful tools in drug discovery and chemical biology. The exploration of it has successfully advanced the field of natural product research. In this Perspective, we survey current strategies for the installation of chemical handles...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356899/ https://www.ncbi.nlm.nih.gov/pubmed/25815285 http://dx.doi.org/10.3389/fchem.2015.00011 |
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author | Zhu, Xuejun Zhang, Wenjun |
author_facet | Zhu, Xuejun Zhang, Wenjun |
author_sort | Zhu, Xuejun |
collection | PubMed |
description | Bioorthogonal chemistry has recently emerged to be one of the most powerful tools in drug discovery and chemical biology. The exploration of it has successfully advanced the field of natural product research. In this Perspective, we survey current strategies for the installation of chemical handles into the molecular scaffolds of several major classes of natural products, including polyketides (PKs), non-ribosomal peptides (NRPs), and their hybrids. By tagging these natural products with chemical handles and coupling them with subsequent bioorthogonal reactions, researchers have visualized and studied the mode of action of natural products, as well as synthesized derivatives with better pharmaceutical properties. We conclude this Perspective by considering two questions: is there a general way to synthesize tagged PKs/NRPs? Does natural product labeling have a broader impact in the field of natural product research beyond current known applications? |
format | Online Article Text |
id | pubmed-4356899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43568992015-03-26 Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications Zhu, Xuejun Zhang, Wenjun Front Chem Chemistry Bioorthogonal chemistry has recently emerged to be one of the most powerful tools in drug discovery and chemical biology. The exploration of it has successfully advanced the field of natural product research. In this Perspective, we survey current strategies for the installation of chemical handles into the molecular scaffolds of several major classes of natural products, including polyketides (PKs), non-ribosomal peptides (NRPs), and their hybrids. By tagging these natural products with chemical handles and coupling them with subsequent bioorthogonal reactions, researchers have visualized and studied the mode of action of natural products, as well as synthesized derivatives with better pharmaceutical properties. We conclude this Perspective by considering two questions: is there a general way to synthesize tagged PKs/NRPs? Does natural product labeling have a broader impact in the field of natural product research beyond current known applications? Frontiers Media S.A. 2015-02-20 /pmc/articles/PMC4356899/ /pubmed/25815285 http://dx.doi.org/10.3389/fchem.2015.00011 Text en Copyright © 2015 Zhu and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Zhu, Xuejun Zhang, Wenjun Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications |
title | Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications |
title_full | Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications |
title_fullStr | Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications |
title_full_unstemmed | Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications |
title_short | Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications |
title_sort | tagging polyketides/non-ribosomal peptides with a clickable functionality and applications |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356899/ https://www.ncbi.nlm.nih.gov/pubmed/25815285 http://dx.doi.org/10.3389/fchem.2015.00011 |
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