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Rightward-biased hemodynamic response of the parahippocampal system during virtual navigation

Phase reset of parahippocampal electrophysiological oscillations in the theta frequency range is said to contribute to item encoding and retrieval during spatial navigation. Although well-studied in non-human animals, this mechanism is poorly understood in humans. Previously we found that feedback s...

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Autores principales: Baker, Travis E., Umemoto, Akina, Krawitz, Adam, Holroyd, Clay B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356951/
https://www.ncbi.nlm.nih.gov/pubmed/25761577
http://dx.doi.org/10.1038/srep09063
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author Baker, Travis E.
Umemoto, Akina
Krawitz, Adam
Holroyd, Clay B.
author_facet Baker, Travis E.
Umemoto, Akina
Krawitz, Adam
Holroyd, Clay B.
author_sort Baker, Travis E.
collection PubMed
description Phase reset of parahippocampal electrophysiological oscillations in the theta frequency range is said to contribute to item encoding and retrieval during spatial navigation. Although well-studied in non-human animals, this mechanism is poorly understood in humans. Previously we found that feedback stimuli presented in a virtual maze environment elicited a burst of theta power over right-posterior areas of the human scalp, and that the power and phase angle of these oscillations were greater following right turns compared to left turns in the maze. Here we investigated the source of this effect with functional magnetic resonance imaging. Consistent with our predictions, we found that 1) feedback encountered in the maze task activated right parahippocampal cortex (PHC), 2) right PHC was more activated by rewards following right turns compared to left turns in the maze, and 3) the rightward-biased activation was more pronounced in individuals who displayed good spatial abilities. These findings support our previous electrophysiological findings and highlight, in humans, a role for PHC theta oscillations in encoding salient information for the purpose of spatial navigation.
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spelling pubmed-43569512015-03-17 Rightward-biased hemodynamic response of the parahippocampal system during virtual navigation Baker, Travis E. Umemoto, Akina Krawitz, Adam Holroyd, Clay B. Sci Rep Article Phase reset of parahippocampal electrophysiological oscillations in the theta frequency range is said to contribute to item encoding and retrieval during spatial navigation. Although well-studied in non-human animals, this mechanism is poorly understood in humans. Previously we found that feedback stimuli presented in a virtual maze environment elicited a burst of theta power over right-posterior areas of the human scalp, and that the power and phase angle of these oscillations were greater following right turns compared to left turns in the maze. Here we investigated the source of this effect with functional magnetic resonance imaging. Consistent with our predictions, we found that 1) feedback encountered in the maze task activated right parahippocampal cortex (PHC), 2) right PHC was more activated by rewards following right turns compared to left turns in the maze, and 3) the rightward-biased activation was more pronounced in individuals who displayed good spatial abilities. These findings support our previous electrophysiological findings and highlight, in humans, a role for PHC theta oscillations in encoding salient information for the purpose of spatial navigation. Nature Publishing Group 2015-03-12 /pmc/articles/PMC4356951/ /pubmed/25761577 http://dx.doi.org/10.1038/srep09063 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Baker, Travis E.
Umemoto, Akina
Krawitz, Adam
Holroyd, Clay B.
Rightward-biased hemodynamic response of the parahippocampal system during virtual navigation
title Rightward-biased hemodynamic response of the parahippocampal system during virtual navigation
title_full Rightward-biased hemodynamic response of the parahippocampal system during virtual navigation
title_fullStr Rightward-biased hemodynamic response of the parahippocampal system during virtual navigation
title_full_unstemmed Rightward-biased hemodynamic response of the parahippocampal system during virtual navigation
title_short Rightward-biased hemodynamic response of the parahippocampal system during virtual navigation
title_sort rightward-biased hemodynamic response of the parahippocampal system during virtual navigation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356951/
https://www.ncbi.nlm.nih.gov/pubmed/25761577
http://dx.doi.org/10.1038/srep09063
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