Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation

Protein-based vaccines require adjuvants to achieve optimal responses. Toll-like receptor (TLR) 9 agonists were previously shown to improve responses to protein-based vaccines, such as the Hepatitis B virus vaccine formulated in alum. Here, we used CpG-C together with the clinically relevant saponin...

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Detalles Bibliográficos
Autores principales: Martinez, Paola, Sundling, Christopher, O'Dell, Sijy, Mascola, John R., Wyatt, Richard T., Karlsson Hedestam, Gunilla B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356977/
https://www.ncbi.nlm.nih.gov/pubmed/25762407
http://dx.doi.org/10.1038/srep08925

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