Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway

BACKGROUND: Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator in cancer cell survival, epithelial-mesenchymal transition, and tumorigenesis. Inhibition of EZH2 has become a promising therapeutic option for various human malignancies. Previously, we demonstrated that the EZH2/miR-30d/k...

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Detalles Bibliográficos
Autores principales: Zhang, Pingyu, Yang, Xianbin, Ma, Xiaoyan, Ingram, Davis R, Lazar, Alexander J, Torres, Keila E, Pollock, Raphael E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357176/
https://www.ncbi.nlm.nih.gov/pubmed/25890085
http://dx.doi.org/10.1186/s12943-015-0325-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357176/
https://www.ncbi.nlm.nih.gov/pubmed/25890085
http://dx.doi.org/10.1186/s12943-015-0325-1

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