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Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway

BACKGROUND: Acute myeloid leukemia (AML) is initiated and maintained by a subset of self-renewing leukemia stem cells (LSCs), which contribute to the progression, recurrence and therapeutic resistance of leukemia. However, the mechanisms underlying the maintenance of LSCs drug resistance have not be...

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Detalles Bibliográficos
Autores principales:	Zhang, Yi, Chen, Hai-xuan, Zhou, Shu-yan, Wang, Shao-xiang, Zheng, Kai, Xu, Dan-dan, Liu, Yu-ting, Wang, Xiao-yan, Wang, Xiao, Yan, Hai-zhao, Zhang, Li, Liu, Qiu-ying, Chen, Wan-qun, Wang, Yi-fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357193/ https://www.ncbi.nlm.nih.gov/pubmed/25890196 http://dx.doi.org/10.1186/s12943-015-0326-0

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