A High-Throughput Screen Reveals New Small-Molecule Activators and Inhibitors of Pantothenate Kinases

[Image: see text] Pantothenate kinase (PanK) is a regulatory enzyme that controls coenzyme A (CoA) biosynthesis. The association of PanK with neurodegeneration and diabetes suggests that chemical modifiers of PanK activity may be useful therapeutics. We performed a high throughput screen of >5200...

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Detalles Bibliográficos
Autores principales: Sharma, Lalit Kumar, Leonardi, Roberta, Lin, Wenwei, Boyd, Vincent A., Goktug, Asli, Shelat, Anang A., Chen, Taosheng, Jackowski, Suzanne, Rock, Charles O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357395/
https://www.ncbi.nlm.nih.gov/pubmed/25569308
http://dx.doi.org/10.1021/jm501585q

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