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Dendritic and axonal mechanisms of Ca(2+) elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons
Disruption of fast axonal transport (FAT) and intracellular Ca(2+) dysregulation are early pathological events in Alzheimer's disease (AD). Amyloid-β oligomers (AβOs), a causative agent of AD, impair transport of BDNF independent of tau by nonexcitotoxic activation of calcineurin (CaN). Ca(2+)-...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The American Society for Cell Biology
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357506/ https://www.ncbi.nlm.nih.gov/pubmed/25609087 http://dx.doi.org/10.1091/mbc.E14-12-1612 |