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Notch and TGF-β pathways cooperatively regulate receptor protein tyrosine phosphatase-κ (PTPRK) gene expression in human primary keratinocytes

Receptor protein tyrosine phosphatase-κ (PTPRK) specifically and directly dephosphorylates epidermal growth factor receptor (EGFR), thereby limiting EGFR function in primary human keratinocytes. PTPRK expression is increased by the TGF-β/Smad3 pathway and cell–cell contact. Because the Notch recepto...

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Detalles Bibliográficos
Autores principales:	Xu, Yiru, Xue, Siliang, Zhou, Jin, Voorhees, John J., Fisher, Gary J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357517/ https://www.ncbi.nlm.nih.gov/pubmed/25609089 http://dx.doi.org/10.1091/mbc.E14-12-1591

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