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A Case Report of Severe Corneal Toxicity following 0.5% Topical Moxifloxacin Use

Moxifloxacin is a widely used topical antibiotic in various bacterial infections of the eye. Its safety and efficacy have been proved by many studies. We report a case of a rare adverse effect following its use. A 10-year-old female who had presented with acute bacterial conjunctivitis in both eyes...

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Autores principales: Vignesh, A.P., Srinivasan, Renuka, Karanth, Swathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357671/
https://www.ncbi.nlm.nih.gov/pubmed/25802507
http://dx.doi.org/10.1159/000376606
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author Vignesh, A.P.
Srinivasan, Renuka
Karanth, Swathi
author_facet Vignesh, A.P.
Srinivasan, Renuka
Karanth, Swathi
author_sort Vignesh, A.P.
collection PubMed
description Moxifloxacin is a widely used topical antibiotic in various bacterial infections of the eye. Its safety and efficacy have been proved by many studies. We report a case of a rare adverse effect following its use. A 10-year-old female who had presented with acute bacterial conjunctivitis in both eyes with no corneal involvement was started on preservative-free 0.5% topical moxifloxacin four times a day. The child developed a severe form of corneal toxicity in both eyes with circumcorneal congestion and corneal edema following its use. The child's visual acuity had dropped from 20/20 to 20/400 in both the eyes. Topical moxifloxacin was discontinued, following which the cornea cleared dramatically and the visual acuity became normal. This case indicates that though rare, topical moxifloxacin can cause severe keratitis and that more studies need to be conducted to evaluate its safety.
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spelling pubmed-43576712015-03-23 A Case Report of Severe Corneal Toxicity following 0.5% Topical Moxifloxacin Use Vignesh, A.P. Srinivasan, Renuka Karanth, Swathi Case Rep Ophthalmol Published online: February, 2015 Moxifloxacin is a widely used topical antibiotic in various bacterial infections of the eye. Its safety and efficacy have been proved by many studies. We report a case of a rare adverse effect following its use. A 10-year-old female who had presented with acute bacterial conjunctivitis in both eyes with no corneal involvement was started on preservative-free 0.5% topical moxifloxacin four times a day. The child developed a severe form of corneal toxicity in both eyes with circumcorneal congestion and corneal edema following its use. The child's visual acuity had dropped from 20/20 to 20/400 in both the eyes. Topical moxifloxacin was discontinued, following which the cornea cleared dramatically and the visual acuity became normal. This case indicates that though rare, topical moxifloxacin can cause severe keratitis and that more studies need to be conducted to evaluate its safety. S. Karger AG 2015-02-13 /pmc/articles/PMC4357671/ /pubmed/25802507 http://dx.doi.org/10.1159/000376606 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: February, 2015
Vignesh, A.P.
Srinivasan, Renuka
Karanth, Swathi
A Case Report of Severe Corneal Toxicity following 0.5% Topical Moxifloxacin Use
title A Case Report of Severe Corneal Toxicity following 0.5% Topical Moxifloxacin Use
title_full A Case Report of Severe Corneal Toxicity following 0.5% Topical Moxifloxacin Use
title_fullStr A Case Report of Severe Corneal Toxicity following 0.5% Topical Moxifloxacin Use
title_full_unstemmed A Case Report of Severe Corneal Toxicity following 0.5% Topical Moxifloxacin Use
title_short A Case Report of Severe Corneal Toxicity following 0.5% Topical Moxifloxacin Use
title_sort case report of severe corneal toxicity following 0.5% topical moxifloxacin use
topic Published online: February, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357671/
https://www.ncbi.nlm.nih.gov/pubmed/25802507
http://dx.doi.org/10.1159/000376606
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