Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance

Many genome maintenance factors have multiple enzymatic activities. In most cases, how their distinct activities functionally relate with each other is unclear. Here we examined the conserved budding yeast Rad5 protein that has both ubiquitin ligase and DNA helicase activities. The Rad5 ubiquitin li...

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Detalles Bibliográficos
Autores principales: Choi, Koyi, Batke, Sabrina, Szakal, Barnabas, Lowther, Jonathan, Hao, Fanfan, Sarangi, Prabha, Branzei, Dana, Ulrich, Helle D., Zhao, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357696/
https://www.ncbi.nlm.nih.gov/pubmed/25690888
http://dx.doi.org/10.1093/nar/gkv004

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