Replication fork integrity and intra-S phase checkpoint suppress gene amplification

Gene amplification is a phenotype-causing form of chromosome instability and is initiated by DNA double-strand breaks (DSBs). Cells with mutant p53 lose G1/S checkpoint and are permissive to gene amplification. In this study we show that mammalian cells become proficient for spontaneous gene amplifi...

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Detalles Bibliográficos
Autores principales: Kondratova, Anna, Watanabe, Takaaki, Marotta, Michael, Cannon, Matthew, Segall, Anca M., Serre, David, Tanaka, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357702/
https://www.ncbi.nlm.nih.gov/pubmed/25672394
http://dx.doi.org/10.1093/nar/gkv084

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