Single-molecule kinetics and footprinting of DNA bis-intercalation: the paradigmatic case of Thiocoraline

DNA bis-intercalators are widely used in molecular biology with applications ranging from DNA imaging to anticancer pharmacology. Two fundamental aspects of these ligands are the lifetime of the bis-intercalated complexes and their sequence selectivity. Here, we perform single-molecule optical tweez...

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Detalles Bibliográficos
Autores principales: Camunas-Soler, Joan, Manosas, Maria, Frutos, Silvia, Tulla-Puche, Judit, Albericio, Fernando, Ritort, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357703/
https://www.ncbi.nlm.nih.gov/pubmed/25690887
http://dx.doi.org/10.1093/nar/gkv087

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