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Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures

We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compa...

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Detalles Bibliográficos
Autores principales:	Lee, Seung-Tae, Muench, Marcus O., Fomin, Marina E., Xiao, Jianqiao, Zhou, Mi, de Smith, Adam, Martín-Subero, José I., Heath, Simon, Houseman, E. Andres, Roy, Ritu, Wrensch, Margaret, Wiencke, John, Metayer, Catherine, Wiemels, Joseph L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357708/ https://www.ncbi.nlm.nih.gov/pubmed/25690899 http://dx.doi.org/10.1093/nar/gkv103

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