CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells

Human ALT cancers show high mutation rates in ATRX and DAXX. Although it is well known that the absence of ATRX/DAXX disrupts H3.3 deposition at heterochromatin, its impact on H3.3 deposition and post-translational modification in the global genome remains unclear. Here, we explore the dynamics of p...

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Detalles Bibliográficos
Autores principales: Chang, Fiona T. M., Chan, F. Lyn, R. McGhie, James D., Udugama, Maheshi, Mayne, Lynne, Collas, Philippe, Mann, Jeffrey R., Wong, Lee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357709/
https://www.ncbi.nlm.nih.gov/pubmed/25690891
http://dx.doi.org/10.1093/nar/gkv104

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