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Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3′ X-tail
A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms the core of an extended pseudoknot, designate...
Autores principales: | Tuplin, Andrew, Struthers, Madeleine, Cook, Jonathan, Bentley, Kirsten, Evans, David J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357731/ https://www.ncbi.nlm.nih.gov/pubmed/25712095 http://dx.doi.org/10.1093/nar/gkv142 |
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