DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes

The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5′-3′ direction...

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Detalles Bibliográficos
Autores principales: Andrade-Lima, Leonardo C., Veloso, Artur, Paulsen, Michelle T., Menck, Carlos F.M., Ljungman, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357734/
https://www.ncbi.nlm.nih.gov/pubmed/25722371
http://dx.doi.org/10.1093/nar/gkv148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357734/
https://www.ncbi.nlm.nih.gov/pubmed/25722371
http://dx.doi.org/10.1093/nar/gkv148

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