Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions

Blood biomarkers may provide a scientifically useful and clinically usable peripheral signal in psychiatry, as they have been doing for other fields of medicine. Jumping to premature conclusions, negative or positive, can create confusion in this field. Reproducibility is a hallmark of good science....

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Autores principales: Niculescu, A B, Levey, D, Le-Niculescu, H, Niculescu, E, Kurian, S M, Salomon, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357859/
https://www.ncbi.nlm.nih.gov/pubmed/25582618
http://dx.doi.org/10.1038/mp.2014.180
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author Niculescu, A B
Levey, D
Le-Niculescu, H
Niculescu, E
Kurian, S M
Salomon, D
author_facet Niculescu, A B
Levey, D
Le-Niculescu, H
Niculescu, E
Kurian, S M
Salomon, D
author_sort Niculescu, A B
collection PubMed
description Blood biomarkers may provide a scientifically useful and clinically usable peripheral signal in psychiatry, as they have been doing for other fields of medicine. Jumping to premature conclusions, negative or positive, can create confusion in this field. Reproducibility is a hallmark of good science. We discuss some recent examples from this dynamic field, and show some new data in support of previously published biomarkers for suicidality (SAT1, MARCKS and SKA2). Methodological clarity and rigor in terms of biomarker discovery, validation and testing is needed. We propose a set of principles for what constitutes a good biomarker, similar in spirit to the Koch postulates used at the birth of the field of infectious diseases.
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spelling pubmed-43578592015-03-27 Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions Niculescu, A B Levey, D Le-Niculescu, H Niculescu, E Kurian, S M Salomon, D Mol Psychiatry Perspective Blood biomarkers may provide a scientifically useful and clinically usable peripheral signal in psychiatry, as they have been doing for other fields of medicine. Jumping to premature conclusions, negative or positive, can create confusion in this field. Reproducibility is a hallmark of good science. We discuss some recent examples from this dynamic field, and show some new data in support of previously published biomarkers for suicidality (SAT1, MARCKS and SKA2). Methodological clarity and rigor in terms of biomarker discovery, validation and testing is needed. We propose a set of principles for what constitutes a good biomarker, similar in spirit to the Koch postulates used at the birth of the field of infectious diseases. Nature Publishing Group 2015-03 2015-01-13 /pmc/articles/PMC4357859/ /pubmed/25582618 http://dx.doi.org/10.1038/mp.2014.180 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Perspective
Niculescu, A B
Levey, D
Le-Niculescu, H
Niculescu, E
Kurian, S M
Salomon, D
Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions
title Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions
title_full Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions
title_fullStr Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions
title_full_unstemmed Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions
title_short Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions
title_sort psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357859/
https://www.ncbi.nlm.nih.gov/pubmed/25582618
http://dx.doi.org/10.1038/mp.2014.180
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