Cargando…

High-Throughput Analysis of Gene Essentiality and Sporulation in Clostridium difficile

Clostridium difficile is the most common cause of antibiotic-associated intestinal infections and a significant cause of morbidity and mortality. Infection with C. difficile requires disruption of the intestinal microbiota, most commonly by antibiotic usage. Therapeutic intervention largely relies o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dembek, Marcin, Barquist, Lars, Boinett, Christine J., Cain, Amy K., Mayho, Matthew, Lawley, Trevor D., Fairweather, Neil F., Fagan, Robert P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358009/ https://www.ncbi.nlm.nih.gov/pubmed/25714712 http://dx.doi.org/10.1128/mBio.02383-14

Ejemplares similares

Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism
por: Pettit, Laura J, et al.
Publicado: (2014)

Global Analysis of the Sporulation Pathway of Clostridium difficile
por: Fimlaid, Kelly A., et al.
Publicado: (2013)

Inducible Expression of spo0A as a Universal Tool for Studying Sporulation in Clostridium difficile
por: Dembek, Marcin, et al.
Publicado: (2017)

Clostridium difficile Cell Wall Protein CwpV Undergoes Enzyme-independent Intramolecular Autoproteolysis
por: Dembek, Marcin, et al.
Publicado: (2012)

Transcriptional Analysis of Temporal Gene Expression in Germinating Clostridium difficile 630 Endospores
por: Dembek, Marcin, et al.
Publicado: (2013)

Approaches to querying bacterial genomes with transposon-insertion sequencing
por: Barquist, Lars, et al.
Publicado: (2013)

The agr Locus Regulates Virulence and Colonization Genes in Clostridium difficile 027
por: Martin, Melissa J., et al.
Publicado: (2013)

The TraDIS toolkit: sequencing and analysis for dense transposon mutant libraries
por: Barquist, Lars, et al.
Publicado: (2016)

Reconsidering the Sporulation Characteristics of Hypervirulent Clostridium difficile BI/NAP1/027
por: Burns, David A., et al.
Publicado: (2011)

A global genomic approach uncovers novel components for twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa
por: Nolan, Laura M., et al.
Publicado: (2018)

Bacteriotherapy for the treatment of intestinal dysbiosis caused by Clostridium difficile infection()
por: Adamu, Blessing O, et al.
Publicado: (2013)

The essential genomic landscape of the commensal Bifidobacterium breve UCC2003
por: Ruiz, Lorena, et al.
Publicado: (2017)

Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong
por: Cheng, V. C. C., et al.
Publicado: (2011)

502. Enhanced Sporulation and Vancomycin Resistance Associated With Clostridium difficile From Recurrent Infections
por: Tijerina-Rodriguez, Laura E, et al.
Publicado: (2018)

Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291
por: Girinathan, Brintha P., et al.
Publicado: (2017)

The Transcriptional Regulator Lrp Contributes to Toxin Expression, Sporulation, and Swimming Motility in Clostridium difficile
por: Chen, Kuan-Yu, et al.
Publicado: (2019)

Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin
por: Cain, Amy K., et al.
Publicado: (2018)

Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment
por: Dembek, Marcin, et al.
Publicado: (2018)

The SOS Response Master Regulator LexA Is Associated with Sporulation, Motility and Biofilm Formation in Clostridium difficile
por: Walter, Beata M., et al.
Publicado: (2015)

Disparate subcellular location of putative sortase substrates in Clostridium difficile
por: Peltier, Johann, et al.
Publicado: (2017)

The Clostridium difficile Cell Wall Protein CwpV is Antigenically Variable between Strains, but Exhibits Conserved Aggregation-Promoting Function
por: Reynolds, Catherine B., et al.
Publicado: (2011)

A novel genetic switch controls phase variable expression of CwpV, a Clostridium difficile cell wall protein
por: Emerson, Jenny E, et al.
Publicado: (2009)

Lighting Up Clostridium Difficile: Reporting Gene Expression Using Fluorescent Lov Domains
por: Buckley, Anthony M., et al.
Publicado: (2016)

Butyrate enhances Clostridioides difficile sporulation in vitro
por: Baldassare, Michelle A., et al.
Publicado: (2023)

Increased toxin expression in a Clostridium difficile mfd mutant
por: Willing, Stephanie E., et al.
Publicado: (2015)

Toxin B is essential for virulence of Clostridium difficile
por: Lyras, Dena, et al.
Publicado: (2009)

Heat shock increases conjugation efficiency in Clostridium difficile()
por: Kirk, Joseph A., et al.
Publicado: (2016)

Increased sporulation underpins adaptation of Clostridium difficile strain 630 to a biologically–relevant faecal environment, with implications for pathogenicity
por: Ternan, Nigel George, et al.
Publicado: (2018)

Emergence of a non-sporulating secondary phenotype in Clostridium (Clostridioides) difficile ribotype 078 isolated from humans and animals
por: Connor, M. C., et al.
Publicado: (2019)

Spatial organization of Clostridium difficile S-layer biogenesis
por: Oatley, Peter, et al.
Publicado: (2020)

Clostridioides difficile Biology: Sporulation, Germination, and Corresponding Therapies for C. difficile Infection
por: Zhu, Duolong, et al.
Publicado: (2018)

High sporulation and overexpression of virulence factors in biofilms and reduced susceptibility to vancomycin and linezolid in recurrent Clostridium [Clostridioides] difficile infection isolates
por: Tijerina-Rodríguez, Laura, et al.
Publicado: (2019)

Characteristics of the Clostridium difficile cell envelope and its importance in therapeutics
por: Kirk, Joseph A., et al.
Publicado: (2016)

Clostridium: Transmission difficile?
por: Harbarth, Stephan, et al.
Publicado: (2012)

As Clear as Mud? Determining the Diversity and Prevalence of Prophages in the Draft Genomes of Estuarine Isolates of Clostridium difficile
por: Hargreaves, Katherine R., et al.
Publicado: (2015)

Dietary trehalose enhances virulence of epidemic Clostridium difficile
por: Collins, J., et al.
Publicado: (2018)

Impact of deoxycholate on Clostridioides difficile growth, toxin production, and sporulation
por: Usui, Yukino, et al.
Publicado: (2020)

c-di-GMP Inhibits Early Sporulation in Clostridioides difficile
por: Edwards, Adrianne N., et al.
Publicado: (2021)

The enteropathogenic Escherichia coli effector NleH inhibits apoptosis induced by Clostridium difficile toxin B
por: Robinson, Keith S., et al.
Publicado: (2010)

Identification of an Essential Region for Translocation of Clostridium difficile Toxin B
por: Chen, Shuyi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_vj44dcd1v8k0chusr4atcailo3