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Microbiota and Mucosal Immunity in Amphibians
We know that animals live in a world dominated by bacteria. In the last 20 years, we have learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and viruses influence different aspects of mucosal development and function. Yet, the literature mainly covers findings obt...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358222/ https://www.ncbi.nlm.nih.gov/pubmed/25821449 http://dx.doi.org/10.3389/fimmu.2015.00111 |
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author | Colombo, Bruno M. Scalvenzi, Thibault Benlamara, Sarah Pollet, Nicolas |
author_facet | Colombo, Bruno M. Scalvenzi, Thibault Benlamara, Sarah Pollet, Nicolas |
author_sort | Colombo, Bruno M. |
collection | PubMed |
description | We know that animals live in a world dominated by bacteria. In the last 20 years, we have learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and viruses influence different aspects of mucosal development and function. Yet, the literature mainly covers findings obtained in mammals. In this review, we focus on two major themes that emerge from the comparative analysis of mammals and amphibians. These themes concern: (i) the structure and functions of lymphoid organs and immune cells in amphibians, with a focus on the gut mucosal immune system; and (ii) the characteristics of the amphibian microbiota and its influence on mucosal immunity. Lastly, we propose to use Xenopus tadpoles as an alternative small-animal model to improve the fundamental knowledge on immunological functions of gut microbiota. |
format | Online Article Text |
id | pubmed-4358222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43582222015-03-27 Microbiota and Mucosal Immunity in Amphibians Colombo, Bruno M. Scalvenzi, Thibault Benlamara, Sarah Pollet, Nicolas Front Immunol Immunology We know that animals live in a world dominated by bacteria. In the last 20 years, we have learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and viruses influence different aspects of mucosal development and function. Yet, the literature mainly covers findings obtained in mammals. In this review, we focus on two major themes that emerge from the comparative analysis of mammals and amphibians. These themes concern: (i) the structure and functions of lymphoid organs and immune cells in amphibians, with a focus on the gut mucosal immune system; and (ii) the characteristics of the amphibian microbiota and its influence on mucosal immunity. Lastly, we propose to use Xenopus tadpoles as an alternative small-animal model to improve the fundamental knowledge on immunological functions of gut microbiota. Frontiers Media S.A. 2015-03-13 /pmc/articles/PMC4358222/ /pubmed/25821449 http://dx.doi.org/10.3389/fimmu.2015.00111 Text en Copyright © 2015 Colombo, Scalvenzi, Benlamara and Pollet. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Colombo, Bruno M. Scalvenzi, Thibault Benlamara, Sarah Pollet, Nicolas Microbiota and Mucosal Immunity in Amphibians |
title | Microbiota and Mucosal Immunity in Amphibians |
title_full | Microbiota and Mucosal Immunity in Amphibians |
title_fullStr | Microbiota and Mucosal Immunity in Amphibians |
title_full_unstemmed | Microbiota and Mucosal Immunity in Amphibians |
title_short | Microbiota and Mucosal Immunity in Amphibians |
title_sort | microbiota and mucosal immunity in amphibians |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358222/ https://www.ncbi.nlm.nih.gov/pubmed/25821449 http://dx.doi.org/10.3389/fimmu.2015.00111 |
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