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Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution
Precise control of protein turnover is essential for cellular homeostasis. The ubiquitin-proteasome system is well established as a major regulator of protein degradation, but an understanding of how inherent structural features influence the lifetimes of proteins is lacking. We report that yeast, m...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358326/ https://www.ncbi.nlm.nih.gov/pubmed/25220455 http://dx.doi.org/10.1016/j.celrep.2014.07.055 |