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The yin and yang of kidney development and Wilms’ tumors

Wilms’ tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors morphologically resemble embryonic kidneys with a disrupted architecture and are associated with undifferentiated metanephric precursors. Here, we discuss genetic and epigenetic findings in Wilms’ tumor in the con...

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Detalles Bibliográficos
Autores principales: Hohenstein, Peter, Pritchard-Jones, Kathy, Charlton, Jocelyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358399/
https://www.ncbi.nlm.nih.gov/pubmed/25737276
http://dx.doi.org/10.1101/gad.256396.114
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author Hohenstein, Peter
Pritchard-Jones, Kathy
Charlton, Jocelyn
author_facet Hohenstein, Peter
Pritchard-Jones, Kathy
Charlton, Jocelyn
author_sort Hohenstein, Peter
collection PubMed
description Wilms’ tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors morphologically resemble embryonic kidneys with a disrupted architecture and are associated with undifferentiated metanephric precursors. Here, we discuss genetic and epigenetic findings in Wilms’ tumor in the context of renal development. Many of the genes implicated in Wilms’ tumorigenesis are involved in the control of nephron progenitors or the microRNA (miRNA) processing pathway. Whereas the first group of genes has been extensively studied in normal development, the second finding suggests important roles for miRNAs in general—and specific miRNAs in particular—in normal kidney development that still await further analysis. The recent identification of Wilms’ tumor cancer stem cells could provide a framework to integrate these pathways and translate them into new or improved therapeutic interventions.
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spelling pubmed-43583992015-09-01 The yin and yang of kidney development and Wilms’ tumors Hohenstein, Peter Pritchard-Jones, Kathy Charlton, Jocelyn Genes Dev Review Wilms’ tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors morphologically resemble embryonic kidneys with a disrupted architecture and are associated with undifferentiated metanephric precursors. Here, we discuss genetic and epigenetic findings in Wilms’ tumor in the context of renal development. Many of the genes implicated in Wilms’ tumorigenesis are involved in the control of nephron progenitors or the microRNA (miRNA) processing pathway. Whereas the first group of genes has been extensively studied in normal development, the second finding suggests important roles for miRNAs in general—and specific miRNAs in particular—in normal kidney development that still await further analysis. The recent identification of Wilms’ tumor cancer stem cells could provide a framework to integrate these pathways and translate them into new or improved therapeutic interventions. Cold Spring Harbor Laboratory Press 2015-03-01 /pmc/articles/PMC4358399/ /pubmed/25737276 http://dx.doi.org/10.1101/gad.256396.114 Text en © 2015 Hohenstein et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Hohenstein, Peter
Pritchard-Jones, Kathy
Charlton, Jocelyn
The yin and yang of kidney development and Wilms’ tumors
title The yin and yang of kidney development and Wilms’ tumors
title_full The yin and yang of kidney development and Wilms’ tumors
title_fullStr The yin and yang of kidney development and Wilms’ tumors
title_full_unstemmed The yin and yang of kidney development and Wilms’ tumors
title_short The yin and yang of kidney development and Wilms’ tumors
title_sort yin and yang of kidney development and wilms’ tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358399/
https://www.ncbi.nlm.nih.gov/pubmed/25737276
http://dx.doi.org/10.1101/gad.256396.114
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