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The yin and yang of kidney development and Wilms’ tumors
Wilms’ tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors morphologically resemble embryonic kidneys with a disrupted architecture and are associated with undifferentiated metanephric precursors. Here, we discuss genetic and epigenetic findings in Wilms’ tumor in the con...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358399/ https://www.ncbi.nlm.nih.gov/pubmed/25737276 http://dx.doi.org/10.1101/gad.256396.114 |
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author | Hohenstein, Peter Pritchard-Jones, Kathy Charlton, Jocelyn |
author_facet | Hohenstein, Peter Pritchard-Jones, Kathy Charlton, Jocelyn |
author_sort | Hohenstein, Peter |
collection | PubMed |
description | Wilms’ tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors morphologically resemble embryonic kidneys with a disrupted architecture and are associated with undifferentiated metanephric precursors. Here, we discuss genetic and epigenetic findings in Wilms’ tumor in the context of renal development. Many of the genes implicated in Wilms’ tumorigenesis are involved in the control of nephron progenitors or the microRNA (miRNA) processing pathway. Whereas the first group of genes has been extensively studied in normal development, the second finding suggests important roles for miRNAs in general—and specific miRNAs in particular—in normal kidney development that still await further analysis. The recent identification of Wilms’ tumor cancer stem cells could provide a framework to integrate these pathways and translate them into new or improved therapeutic interventions. |
format | Online Article Text |
id | pubmed-4358399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-43583992015-09-01 The yin and yang of kidney development and Wilms’ tumors Hohenstein, Peter Pritchard-Jones, Kathy Charlton, Jocelyn Genes Dev Review Wilms’ tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors morphologically resemble embryonic kidneys with a disrupted architecture and are associated with undifferentiated metanephric precursors. Here, we discuss genetic and epigenetic findings in Wilms’ tumor in the context of renal development. Many of the genes implicated in Wilms’ tumorigenesis are involved in the control of nephron progenitors or the microRNA (miRNA) processing pathway. Whereas the first group of genes has been extensively studied in normal development, the second finding suggests important roles for miRNAs in general—and specific miRNAs in particular—in normal kidney development that still await further analysis. The recent identification of Wilms’ tumor cancer stem cells could provide a framework to integrate these pathways and translate them into new or improved therapeutic interventions. Cold Spring Harbor Laboratory Press 2015-03-01 /pmc/articles/PMC4358399/ /pubmed/25737276 http://dx.doi.org/10.1101/gad.256396.114 Text en © 2015 Hohenstein et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Hohenstein, Peter Pritchard-Jones, Kathy Charlton, Jocelyn The yin and yang of kidney development and Wilms’ tumors |
title | The yin and yang of kidney development and Wilms’ tumors |
title_full | The yin and yang of kidney development and Wilms’ tumors |
title_fullStr | The yin and yang of kidney development and Wilms’ tumors |
title_full_unstemmed | The yin and yang of kidney development and Wilms’ tumors |
title_short | The yin and yang of kidney development and Wilms’ tumors |
title_sort | yin and yang of kidney development and wilms’ tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358399/ https://www.ncbi.nlm.nih.gov/pubmed/25737276 http://dx.doi.org/10.1101/gad.256396.114 |
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