The DREAM complex promotes gene body H2A.Z for target repression

The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of l...

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Autores principales: Latorre, Isabel, Chesney, Michael A., Garrigues, Jacob M., Stempor, Przemyslaw, Appert, Alex, Francesconi, Mirko, Strome, Susan, Ahringer, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358402/
https://www.ncbi.nlm.nih.gov/pubmed/25737279
http://dx.doi.org/10.1101/gad.255810.114
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author Latorre, Isabel
Chesney, Michael A.
Garrigues, Jacob M.
Stempor, Przemyslaw
Appert, Alex
Francesconi, Mirko
Strome, Susan
Ahringer, Julie
author_facet Latorre, Isabel
Chesney, Michael A.
Garrigues, Jacob M.
Stempor, Przemyslaw
Appert, Alex
Francesconi, Mirko
Strome, Susan
Ahringer, Julie
author_sort Latorre, Isabel
collection PubMed
description The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and increased expression. Consistent with a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/H2A.Z mutants. Our results indicate that the DREAM complex facilitates high gene body HTZ-1/H2A.Z, which plays a role in target gene repression.
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spelling pubmed-43584022015-03-16 The DREAM complex promotes gene body H2A.Z for target repression Latorre, Isabel Chesney, Michael A. Garrigues, Jacob M. Stempor, Przemyslaw Appert, Alex Francesconi, Mirko Strome, Susan Ahringer, Julie Genes Dev Research Communication The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and increased expression. Consistent with a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/H2A.Z mutants. Our results indicate that the DREAM complex facilitates high gene body HTZ-1/H2A.Z, which plays a role in target gene repression. Cold Spring Harbor Laboratory Press 2015-03-01 /pmc/articles/PMC4358402/ /pubmed/25737279 http://dx.doi.org/10.1101/gad.255810.114 Text en © 2015 Latorre et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by/4.0/ This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Communication
Latorre, Isabel
Chesney, Michael A.
Garrigues, Jacob M.
Stempor, Przemyslaw
Appert, Alex
Francesconi, Mirko
Strome, Susan
Ahringer, Julie
The DREAM complex promotes gene body H2A.Z for target repression
title The DREAM complex promotes gene body H2A.Z for target repression
title_full The DREAM complex promotes gene body H2A.Z for target repression
title_fullStr The DREAM complex promotes gene body H2A.Z for target repression
title_full_unstemmed The DREAM complex promotes gene body H2A.Z for target repression
title_short The DREAM complex promotes gene body H2A.Z for target repression
title_sort dream complex promotes gene body h2a.z for target repression
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358402/
https://www.ncbi.nlm.nih.gov/pubmed/25737279
http://dx.doi.org/10.1101/gad.255810.114
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