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FDA approved drugs as potential Ebola treatments

In the search for treatments for the Ebola Virus, multiple screens of FDA drugs have led to the identification of several with promising in vitro activity. These compounds were not originally developed as antivirals and some have been further tested in mouse in vivo models. We put forward the opinio...

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Detalles Bibliográficos
Autores principales: Ekins, Sean, Coffee, Megan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358410/
https://www.ncbi.nlm.nih.gov/pubmed/25789163
http://dx.doi.org/10.12688/f1000research.6164.2
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author Ekins, Sean
Coffee, Megan
author_facet Ekins, Sean
Coffee, Megan
author_sort Ekins, Sean
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description In the search for treatments for the Ebola Virus, multiple screens of FDA drugs have led to the identification of several with promising in vitro activity. These compounds were not originally developed as antivirals and some have been further tested in mouse in vivo models. We put forward the opinion that some of these drugs could be evaluated further and move into the clinic as they are already FDA approved and in many cases readily available. This may be important if there is a further outbreak in future and no other therapeutic is available.
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spelling pubmed-43584102015-03-17 FDA approved drugs as potential Ebola treatments Ekins, Sean Coffee, Megan F1000Res Opinion Article In the search for treatments for the Ebola Virus, multiple screens of FDA drugs have led to the identification of several with promising in vitro activity. These compounds were not originally developed as antivirals and some have been further tested in mouse in vivo models. We put forward the opinion that some of these drugs could be evaluated further and move into the clinic as they are already FDA approved and in many cases readily available. This may be important if there is a further outbreak in future and no other therapeutic is available. F1000Research 2015-03-10 /pmc/articles/PMC4358410/ /pubmed/25789163 http://dx.doi.org/10.12688/f1000research.6164.2 Text en Copyright: © 2015 Ekins S and Coffee M http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).
spellingShingle Opinion Article
Ekins, Sean
Coffee, Megan
FDA approved drugs as potential Ebola treatments
title FDA approved drugs as potential Ebola treatments
title_full FDA approved drugs as potential Ebola treatments
title_fullStr FDA approved drugs as potential Ebola treatments
title_full_unstemmed FDA approved drugs as potential Ebola treatments
title_short FDA approved drugs as potential Ebola treatments
title_sort fda approved drugs as potential ebola treatments
topic Opinion Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358410/
https://www.ncbi.nlm.nih.gov/pubmed/25789163
http://dx.doi.org/10.12688/f1000research.6164.2
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