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Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats

Methadone and buprenorphine are widely used for treating people with opioid dependence, including pregnant women. Prenatal exposure to opioids has devastating effects on the development of human fetuses and may induce long-term physical and neurobehavioral changes during postnatal maturation. This s...

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Autores principales: Chen, Hwei-Hsien, Chiang, Yao-Chang, Yuan, Zung Fan, Kuo, Chung-Chih, Lai, Mei-Dan, Hung, Tsai-Wei, Ho, Ing-kang, Chen, Shao-Tsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358634/
https://www.ncbi.nlm.nih.gov/pubmed/25834439
http://dx.doi.org/10.2147/NDT.S70585
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author Chen, Hwei-Hsien
Chiang, Yao-Chang
Yuan, Zung Fan
Kuo, Chung-Chih
Lai, Mei-Dan
Hung, Tsai-Wei
Ho, Ing-kang
Chen, Shao-Tsu
author_facet Chen, Hwei-Hsien
Chiang, Yao-Chang
Yuan, Zung Fan
Kuo, Chung-Chih
Lai, Mei-Dan
Hung, Tsai-Wei
Ho, Ing-kang
Chen, Shao-Tsu
author_sort Chen, Hwei-Hsien
collection PubMed
description Methadone and buprenorphine are widely used for treating people with opioid dependence, including pregnant women. Prenatal exposure to opioids has devastating effects on the development of human fetuses and may induce long-term physical and neurobehavioral changes during postnatal maturation. This study aimed at comparing the behavioral outcomes of young rats prenatally exposed to buprenorphine, methadone, and morphine. Pregnant Sprague-Dawley rats were administered saline, morphine, methadone, and buprenorphine during embryonic days 3–20. The cognitive function, social interaction, anxiety-like behaviors, and locomotor activity of offsprings were examined by novel object recognition test, social interaction test, light–dark transition test, elevated plus-maze, and open-field test between 6 weeks and 10 weeks of age. Prenatal exposure to methadone and buprenorphine did not affect locomotor activity, but significantly impaired novel object recognition and social interaction in both male and female offsprings in the same manner as morphine. Although prenatal exposure to methadone or buprenorphine increased anxiety-like behaviors in the light–dark transition in both male and female offsprings, the effects were less pronounced as compared to that of morphine. Methadone affected elevated plus-maze in both sex, but buprenorphine only affected the female offsprings. These findings suggest that buprenorphine and methadone maintenance therapy for pregnant women, like morphine, produced detrimental effects on cognitive function and social behaviors, whereas the offsprings of such women might have a lower risk of developing anxiety disorders.
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spelling pubmed-43586342015-04-01 Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats Chen, Hwei-Hsien Chiang, Yao-Chang Yuan, Zung Fan Kuo, Chung-Chih Lai, Mei-Dan Hung, Tsai-Wei Ho, Ing-kang Chen, Shao-Tsu Neuropsychiatr Dis Treat Original Research Methadone and buprenorphine are widely used for treating people with opioid dependence, including pregnant women. Prenatal exposure to opioids has devastating effects on the development of human fetuses and may induce long-term physical and neurobehavioral changes during postnatal maturation. This study aimed at comparing the behavioral outcomes of young rats prenatally exposed to buprenorphine, methadone, and morphine. Pregnant Sprague-Dawley rats were administered saline, morphine, methadone, and buprenorphine during embryonic days 3–20. The cognitive function, social interaction, anxiety-like behaviors, and locomotor activity of offsprings were examined by novel object recognition test, social interaction test, light–dark transition test, elevated plus-maze, and open-field test between 6 weeks and 10 weeks of age. Prenatal exposure to methadone and buprenorphine did not affect locomotor activity, but significantly impaired novel object recognition and social interaction in both male and female offsprings in the same manner as morphine. Although prenatal exposure to methadone or buprenorphine increased anxiety-like behaviors in the light–dark transition in both male and female offsprings, the effects were less pronounced as compared to that of morphine. Methadone affected elevated plus-maze in both sex, but buprenorphine only affected the female offsprings. These findings suggest that buprenorphine and methadone maintenance therapy for pregnant women, like morphine, produced detrimental effects on cognitive function and social behaviors, whereas the offsprings of such women might have a lower risk of developing anxiety disorders. Dove Medical Press 2015-03-06 /pmc/articles/PMC4358634/ /pubmed/25834439 http://dx.doi.org/10.2147/NDT.S70585 Text en © 2015 Chen et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Chen, Hwei-Hsien
Chiang, Yao-Chang
Yuan, Zung Fan
Kuo, Chung-Chih
Lai, Mei-Dan
Hung, Tsai-Wei
Ho, Ing-kang
Chen, Shao-Tsu
Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats
title Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats
title_full Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats
title_fullStr Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats
title_full_unstemmed Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats
title_short Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats
title_sort buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358634/
https://www.ncbi.nlm.nih.gov/pubmed/25834439
http://dx.doi.org/10.2147/NDT.S70585
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