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Declining transition/transversion ratios through time reveal limitations to the accuracy of nucleotide substitution models

BACKGROUND: Genetic analyses of DNA sequences make use of an increasingly complex set of nucleotide substitution models to estimate the divergence between gene sequences. However, there is currently no way to assess the validity of nucleotide substitution models over short time-scales and with limit...

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Detalles Bibliográficos
Autores principales:	Duchêne, Sebastián, Ho, Simon YW, Holmes, Edward C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358783/ https://www.ncbi.nlm.nih.gov/pubmed/25886870 http://dx.doi.org/10.1186/s12862-015-0312-6

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