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Developmental programming: the role of growth hormone

Developmental programming of the fetus has consequences for physiologic responses in the offspring as an adult and, more recently, is implicated in the expression of altered phenotypes of future generations. Some phenotypes, such as fertility, bone strength, and adiposity are highly relevant to food...

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Detalles Bibliográficos
Autor principal: Oberbauer, Anita M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358872/
https://www.ncbi.nlm.nih.gov/pubmed/25774292
http://dx.doi.org/10.1186/s40104-015-0001-8
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author Oberbauer, Anita M
author_facet Oberbauer, Anita M
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description Developmental programming of the fetus has consequences for physiologic responses in the offspring as an adult and, more recently, is implicated in the expression of altered phenotypes of future generations. Some phenotypes, such as fertility, bone strength, and adiposity are highly relevant to food animal production and in utero factors that impinge on those traits are vital to understand. A key systemic regulatory hormone is growth hormone (GH), which has a developmental role in virtually all tissues and organs. This review catalogs the impact of GH on tissue programming and how perturbations early in development influence GH function.
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spelling pubmed-43588722015-03-14 Developmental programming: the role of growth hormone Oberbauer, Anita M J Anim Sci Biotechnol Review Developmental programming of the fetus has consequences for physiologic responses in the offspring as an adult and, more recently, is implicated in the expression of altered phenotypes of future generations. Some phenotypes, such as fertility, bone strength, and adiposity are highly relevant to food animal production and in utero factors that impinge on those traits are vital to understand. A key systemic regulatory hormone is growth hormone (GH), which has a developmental role in virtually all tissues and organs. This review catalogs the impact of GH on tissue programming and how perturbations early in development influence GH function. BioMed Central 2015-02-12 /pmc/articles/PMC4358872/ /pubmed/25774292 http://dx.doi.org/10.1186/s40104-015-0001-8 Text en © Oberbauer; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Oberbauer, Anita M
Developmental programming: the role of growth hormone
title Developmental programming: the role of growth hormone
title_full Developmental programming: the role of growth hormone
title_fullStr Developmental programming: the role of growth hormone
title_full_unstemmed Developmental programming: the role of growth hormone
title_short Developmental programming: the role of growth hormone
title_sort developmental programming: the role of growth hormone
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358872/
https://www.ncbi.nlm.nih.gov/pubmed/25774292
http://dx.doi.org/10.1186/s40104-015-0001-8
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