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Production of Anti-LPS IgM by B1a B Cells Depends on IL-1β and Is Protective against Lung Infection with Francisella tularensis LVS

The role of IL-1β and IL-18 during lung infection with the gram-negative bacterium Francisella tularensis LVS has not been characterized in detail. Here, using a mouse model of pneumonic tularemia, we show that both cytokines are protective, but through different mechanisms. Il-18(-/-) mice quickly...

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Detalles Bibliográficos
Autores principales:	del Barrio, Laura, Sahoo, Manoranjan, Lantier, Louis, Reynolds, Joseph M., Ceballos-Olvera, Ivonne, Re, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358995/ https://www.ncbi.nlm.nih.gov/pubmed/25768794 http://dx.doi.org/10.1371/journal.ppat.1004706

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