Bayesian dose-finding designs for combination of molecularly targeted agents assuming partial stochastic ordering

Molecularly targeted agent (MTA) combination therapy is in the early stages of development. When using a fixed dose of one agent in combinations of MTAs, toxicity and efficacy do not necessarily increase with an increasing dose of the other agent. Thus, in dose-finding trials for combinations of MTA...

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Detalles Bibliográficos
Autores principales: Guo, Beibei, Li, Yisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359011/
https://www.ncbi.nlm.nih.gov/pubmed/25413162
http://dx.doi.org/10.1002/sim.6376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359011/
https://www.ncbi.nlm.nih.gov/pubmed/25413162
http://dx.doi.org/10.1002/sim.6376

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