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Bayesian dose-finding designs for combination of molecularly targeted agents assuming partial stochastic ordering
Molecularly targeted agent (MTA) combination therapy is in the early stages of development. When using a fixed dose of one agent in combinations of MTAs, toxicity and efficacy do not necessarily increase with an increasing dose of the other agent. Thus, in dose-finding trials for combinations of MTA...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BlackWell Publishing Ltd
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359011/ https://www.ncbi.nlm.nih.gov/pubmed/25413162 http://dx.doi.org/10.1002/sim.6376 |