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In Silico Screening, Genotyping, Molecular Dynamics Simulation and Activity Studies of SNPs in Pyruvate Kinase M2

Role of, 29-non-synonymous, 15-intronic, 3-close to UTR, single nucleotide polymorphisms (SNPs) and 2 mutations of Human Pyruvate Kinase (PK) M2 were investigated by in-silico and in-vitro functional studies. Prediction of deleterious substitutions based on sequence homology and structure based serv...

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Detalles Bibliográficos
Autores principales:	Kalaiarasan, Ponnusamy, Kumar, Bhupender, Chopra, Rupali, Gupta, Vibhor, Subbarao, Naidu, Bamezai, Rameshwar N. K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359060/ https://www.ncbi.nlm.nih.gov/pubmed/25768091 http://dx.doi.org/10.1371/journal.pone.0120469

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