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Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells
Approximately half of poor prognosis neuroblastomas (NBs) are characterized by pathognomonic MYCN gene amplification and MYCN over‐expression. Here we present data showing that short‐interfering RNA mediated depletion of the protein arginine methyltransferase 5 (PRMT5) in cell‐lines representative o...
Autores principales: | Park, Ji Hyun, Szemes, Marianna, Vieira, Gabriella Cunha, Melegh, Zsombor, Malik, Sally, Heesom, Kate J., Von Wallwitz-Freitas, Laura, Greenhough, Alexander, Brown, Keith W., Zheng, Y. George, Catchpoole, Daniel, Deery, Michael J., Malik, Karim |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359099/ https://www.ncbi.nlm.nih.gov/pubmed/25475372 http://dx.doi.org/10.1016/j.molonc.2014.10.015 |
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