Exploring phosphatidylinositol 5-phosphate 4-kinase function

The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, int...

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Detalles Bibliográficos
Autores principales: Bulley, Simon J., Clarke, Jonathan H., Droubi, Alaa, Giudici, Maria-Luisa, Irvine, Robin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359101/
https://www.ncbi.nlm.nih.gov/pubmed/25311266
http://dx.doi.org/10.1016/j.jbior.2014.09.007
Descripción
Sumario:The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, interaction, and regulation and also we summarise our current understanding of how PI5P is synthesised and what its cellular functions might be. Finally, some of the evidence for the involvement of PI5P4Ks in pathology is discussed.

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