Exploring phosphatidylinositol 5-phosphate 4-kinase function

The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, int...

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Detalles Bibliográficos
Autores principales: Bulley, Simon J., Clarke, Jonathan H., Droubi, Alaa, Giudici, Maria-Luisa, Irvine, Robin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359101/
https://www.ncbi.nlm.nih.gov/pubmed/25311266
http://dx.doi.org/10.1016/j.jbior.2014.09.007
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author Bulley, Simon J.
Clarke, Jonathan H.
Droubi, Alaa
Giudici, Maria-Luisa
Irvine, Robin F.
author_facet Bulley, Simon J.
Clarke, Jonathan H.
Droubi, Alaa
Giudici, Maria-Luisa
Irvine, Robin F.
author_sort Bulley, Simon J.
collection PubMed
description The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, interaction, and regulation and also we summarise our current understanding of how PI5P is synthesised and what its cellular functions might be. Finally, some of the evidence for the involvement of PI5P4Ks in pathology is discussed.
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spelling pubmed-43591012015-03-31 Exploring phosphatidylinositol 5-phosphate 4-kinase function Bulley, Simon J. Clarke, Jonathan H. Droubi, Alaa Giudici, Maria-Luisa Irvine, Robin F. Adv Biol Regul Article The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, interaction, and regulation and also we summarise our current understanding of how PI5P is synthesised and what its cellular functions might be. Finally, some of the evidence for the involvement of PI5P4Ks in pathology is discussed. Elsevier 2015-01 /pmc/articles/PMC4359101/ /pubmed/25311266 http://dx.doi.org/10.1016/j.jbior.2014.09.007 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Bulley, Simon J.
Clarke, Jonathan H.
Droubi, Alaa
Giudici, Maria-Luisa
Irvine, Robin F.
Exploring phosphatidylinositol 5-phosphate 4-kinase function
title Exploring phosphatidylinositol 5-phosphate 4-kinase function
title_full Exploring phosphatidylinositol 5-phosphate 4-kinase function
title_fullStr Exploring phosphatidylinositol 5-phosphate 4-kinase function
title_full_unstemmed Exploring phosphatidylinositol 5-phosphate 4-kinase function
title_short Exploring phosphatidylinositol 5-phosphate 4-kinase function
title_sort exploring phosphatidylinositol 5-phosphate 4-kinase function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359101/
https://www.ncbi.nlm.nih.gov/pubmed/25311266
http://dx.doi.org/10.1016/j.jbior.2014.09.007
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