Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells

Dormant or slow-cycling disseminated tumor cells (DTCs) in bone marrow (BM) are resistant to conventional therapy in various cancers including head and neck squamous cell carcinoma (HNSCC), although the molecular mechanisms remain largely unknown. This study aimed to identify the intrinsic molecular...

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Detalles Bibliográficos
Autores principales: Nakamura, Takuya, Shinriki, Satoru, Jono, Hirofumi, Guo, Jianying, Ueda, Mitsuharu, Hayashi, Mitsuhiro, Yamashita, Satoshi, Zijlstra, Andries, Nakayama, Hideki, Hiraki, Akimitsu, Shinohara, Masanori, Ando, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359213/
https://www.ncbi.nlm.nih.gov/pubmed/25504440

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