Cargando…

Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype

Pancreatic cancer (PC) is one of the leading causes of cancer related deaths due to aggressive progression and metastatic spread. Aspartate β-hydroxylase (ASPH), a cell surface protein that catalyzes the hydroxylation of epidermal growth factor (EGF)-like repeats in Notch receptors and ligands, is h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Xiaoqun, Lin, Qiushi, Aihara, Arihiro, Li, Yu, Huang, Chiung-Kuei, Chung, Waihong, Tang, Qi, Chen, Xuesong, Carlson, Rolf, Nadolny, Christina, Gabriel, Gregory, Olsen, Mark, Wands, Jack R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359229/ https://www.ncbi.nlm.nih.gov/pubmed/25483102

Ejemplares similares

Correction: Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype
por: Dong, Xiaoqun, et al.
Publicado: (2019)

Anti-Tumor Effects of Second Generation β-Hydroxylase Inhibitors on Cholangiocarcinoma Development and Progression
por: Huang, Chiung-Kuei, et al.
Publicado: (2016)

Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway
por: Ogawa, Kosuke, et al.
Publicado: (2019)

Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases
por: Chung, Waihong, et al.
Publicado: (2020)

Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas
por: Sturla, Lisa-Marie, et al.
Publicado: (2016)

Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase
por: Shapiro, Jason M., et al.
Publicado: (2016)

Endocrine sensitivity of estrogen receptor‐positive breast cancer is negatively correlated with aspartate‐β‐hydroxylase expression
por: Shimoda, Masafumi, et al.
Publicado: (2017)

Aspartate β-hydroxylase as a target for cancer therapy
por: Kanwal, Madiha, et al.
Publicado: (2020)

A Novel Drug, CC-122, Inhibits Tumor Growth in Hepatocellular Carcinoma through Downregulation of an Oncogenic TCF-4 Isoform()()
por: Tomimaru, Yoshito, et al.
Publicado: (2019)

Diverse molecular functions of aspartate β-hydroxylase in cancer
por: Zheng, Wenqian, et al.
Publicado: (2020)

Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer
por: Benelli, Roberto, et al.
Publicado: (2020)

Aspartate β-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma
por: Tang, C, et al.
Publicado: (2017)

Characterization of the Relationship Between the Expression of Aspartate β-Hydroxylase and the Pathological Characteristics of Breast Cancer
por: Zhang, Yanan, et al.
Publicado: (2020)

Aspartate β-Hydroxylase Serves as a Prognostic Biomarker for Neoadjuvant Chemotherapy in Gastric Cancer
por: Gan, Xuejun, et al.
Publicado: (2023)

Aspartyl-(asparaginyl) β-Hydroxylase, Hypoxia-Inducible Factor-1α and Notch Cross-Talk in Regulating Neuronal Motility
por: Lawton, Margot, et al.
Publicado: (2010)

Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Novel Approach to Overcome Defects of Cell-SELEX in Developing Aptamers against Aspartate β-Hydroxylase
por: Bakhtiari, Hadi, et al.
Publicado: (2021)

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Construction and Characterization of Adenovirus Vectors Encoding Aspartate-β-Hydroxylase to Preliminary Application in Immunotherapy of Hepatocellular Carcinoma
por: Zhou, Yujiao, et al.
Publicado: (2018)

Aspartate β-Hydroxylase (ASPH) Expression in Acute Myeloid Leukemia: A Potential Novel Therapeutic Target
por: Holtzman, Noa G., et al.
Publicado: (2021)

Differential growth factor regulation of aspartyl-(asparaginyl)-β-hydroxylase family genes in SH-Sy5y human neuroblastoma cells
por: Lahousse, Stephanie A, et al.
Publicado: (2006)

X-ray Scatter Imaging of Hepatocellular Carcinoma in a Mouse Model Using Nanoparticle Contrast Agents
por: Rand, Danielle, et al.
Publicado: (2015)

Corrigendum: X-ray Scatter Imaging of Hepatocellular Carcinoma in a Mouse Model Using Nanoparticle Contrast Agents
por: Rand, Danielle, et al.
Publicado: (2016)

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing
por: Brewitz, Lennart, et al.
Publicado: (2020)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

Erratum: Benelli, R., et al. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. Cancers 2020, 12, 971
por: Benelli, Roberto, et al.
Publicado: (2020)

Aspartate beta-hydroxylase domain containing 1 as a prognostic marker associated with immune infiltration in skin cutaneous melanoma
por: Sun, Shiquan, et al.
Publicado: (2023)

ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis
por: Lin, Qiushi, et al.
Publicado: (2019)

Lambda phage-based vaccine induces antitumor immunity in hepatocellular carcinoma
por: Iwagami, Yoshifumi, et al.
Publicado: (2017)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
por: Pfeffer, Inga, et al.
Publicado: (2019)

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

A biosynthetic aspartate N-hydroxylase performs successive oxidations by holding intermediates at a site away from the catalytic center
por: Rotilio, Laura, et al.
Publicado: (2023)

Adaptive antitumor immune response stimulated by bio-nanoparticle based vaccine and checkpoint blockade
por: Bai, Xuewei, et al.
Publicado: (2022)

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
por: Durán, R V, et al.
Publicado: (2013)

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
por: Yeh, Tzu-Lan, et al.
Publicado: (2017)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
por: Masson, Norma, et al.
Publicado: (2012)

Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function
por: Hoang, Monica, et al.
Publicado: (2021)

Induction of Cannabinoid- and N-Methyl-d-Aspartate Receptor-Mediated Long-Term Depression in the Nucleus Accumbens and Dorsolateral Striatum Is Region and Age Dependent
por: Zhang, Xiaoqun, et al.
Publicado: (2015)

DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity
por: Parveen, Nazia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_k7gfl5rm953jrfm9hg7ud73et7