Androgen receptors beyond prostate cancer: an old marker as a new target

Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy. Despite mounting evidence that ARs also participate in the pathogenesis and/or progression of diverse tumors, exploring the impact of hormonal...

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Detalles Bibliográficos
Autores principales: Munoz, Javier, Wheler, Jennifer J., Kurzrock, Razelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359241/
https://www.ncbi.nlm.nih.gov/pubmed/25595907
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author Munoz, Javier
Wheler, Jennifer J.
Kurzrock, Razelle
author_facet Munoz, Javier
Wheler, Jennifer J.
Kurzrock, Razelle
author_sort Munoz, Javier
collection PubMed
description Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy. Despite mounting evidence that ARs also participate in the pathogenesis and/or progression of diverse tumors, exploring the impact of hormonal manipulation of these receptors has not been widely pursued beyond prostate cancer. This review describes patterns of AR expression in a spectrum of cancers, and the potential to exploit this knowledge in the clinical therapeutic setting.
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spelling pubmed-43592412015-03-27 Androgen receptors beyond prostate cancer: an old marker as a new target Munoz, Javier Wheler, Jennifer J. Kurzrock, Razelle Oncotarget Review Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy. Despite mounting evidence that ARs also participate in the pathogenesis and/or progression of diverse tumors, exploring the impact of hormonal manipulation of these receptors has not been widely pursued beyond prostate cancer. This review describes patterns of AR expression in a spectrum of cancers, and the potential to exploit this knowledge in the clinical therapeutic setting. Impact Journals LLC 2014-11-15 /pmc/articles/PMC4359241/ /pubmed/25595907 Text en Copyright: © 2015 Munoz et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Munoz, Javier
Wheler, Jennifer J.
Kurzrock, Razelle
Androgen receptors beyond prostate cancer: an old marker as a new target
title Androgen receptors beyond prostate cancer: an old marker as a new target
title_full Androgen receptors beyond prostate cancer: an old marker as a new target
title_fullStr Androgen receptors beyond prostate cancer: an old marker as a new target
title_full_unstemmed Androgen receptors beyond prostate cancer: an old marker as a new target
title_short Androgen receptors beyond prostate cancer: an old marker as a new target
title_sort androgen receptors beyond prostate cancer: an old marker as a new target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359241/
https://www.ncbi.nlm.nih.gov/pubmed/25595907
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