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IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment
IL-1 is key driver of gastric tumorigenesis and is a downstream target of IL-11 signaling. Recently, IL-1 cytokines, particularly IL-1β, have been flagged as therapeutic targets for gastric cancer treatment. Here, we assess the requirement for IL-1 signaling in gastric tumorigenesis. gp130(757FF) xI...
Autores principales: | Buzzelli, Jon N., Pavlic, Dan I., Chalinor, Heather V., O'Connor, Louise, Menheniott, Trevelyan R., Giraud, Andrew S., Judd, Louise M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359248/ https://www.ncbi.nlm.nih.gov/pubmed/25528766 |
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