SWI/SNF complexes are required for full activation of the DNA-damage response

SWI/SNF complexes utilize BRG1 (also known as SMARCA4) or BRM (also known as SMARCA2) as alternative catalytic subunits with ATPase activity to remodel chromatin. These chromatin-remodeling complexes are required for mammalian development and are mutated in ~20% of all human primary tumors. Yet our...

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Detalles Bibliográficos
Autores principales: Smith-Roe, Stephanie L., Nakamura, Jun, Holley, Darcy, Chastain, Paul D., Rosson, Gary B., Simpson, Dennis A., Ridpath, John R., Kaufman, David G., Kaufmann, William K., Bultman, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359251/
https://www.ncbi.nlm.nih.gov/pubmed/25544751

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