Silencing of WNK2 is associated with upregulation of MMP2 and JNK in gliomas

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade extracellular matrix (ECM), thus assisting invasion. Upregulation of MMPs, frequently reported in gliomas, is associated with aggressive behavior. WNK2 is a tumor suppressor gene expressed in normal brain, and silenced by promoter...

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Detalles Bibliográficos
Autores principales: Costa, Angela Margarida, Pinto, Filipe, Martinho, Olga, Oliveira, Maria José, Jordan, Peter, Reis, Rui Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359304/
https://www.ncbi.nlm.nih.gov/pubmed/25596741

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